My belief is that a good programming interface for reconfigurable systems will be necessary for future chips. I believe that manufacturing considerations for future nanoscale ICs will proove fault-tolerant fabrics to be the optimal chip structure. Years beyond that amorphous and self-assembing cellular structures are likely to replace the fabrication methods of today. It is likely that these devices will be extremely difficult to program so I'd better think about it now if I want a head-start.
A friend of mine said: "we've been doing von Neumann for 50 years, we couldn't have gotten it right the first time."